Journal of Indian Academy of Oral Medicine and Radiology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 30  |  Issue : 3  |  Page : 235--240

Comparative evaluation of the efficacy of topical amlexanox 5% oral paste and triamcinolone acetonide 0.1% oral paste in the treatment of Recurrent Aphthous Stomatitis (RAS)


K Shrivastava, G Naidu, A Deshpande, H Handa, V Raghuvanshi, M Gupta 
 Department of Oral Medicine and Radiology, Rishi Raj College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India

Correspondence Address:
Dr. K Shrivastava
Department of Oral Medicine and Radiology, Rishi Raj College of Dental Sciences and Research Centre, Bhopal - 462 026, Madhya Pradesh
India

Background: A double-blind randomized control trial was conducted to compare the clinical efficacy of topical triamcinolone acetonide 0.1% and amlexanox 5% in recurrent apthous stomatitis (minor). Materials and Methods: Forty adult patients were assessed for erythema, ulcer size, pain scores, and ulcer healing on three evaluation visits within 24 h of ulcer formation, third day, and fifth day. All participants were monitored for compliance with treatment protocols of four times daily application of calibrated quantity of medication. Results and Discussion: Ninety percent of controls when compared with 65% of the participants in the amlexanox group showed complete improvement of peri-ulcer erythema. Pain reduction was marked from the first to the fifth day (F = 15.249, P = 0.000). The control participants showed 90% reduction in pain in comparison to 70% in the amlexanox group. The mean ulcer size was shown to reduce from the first to fifth day in both groups (F = 18.611, P = 0.000). Completely healed ulcers were seen in 70% of the participants in the control group compared with 75% of the participants in the amlexanox group. Conclusion: The data suggest that the clinical efficacy of topical amlexanox 5% is comparable to topical 0.1% triamcinolone acetonide and may be considered a substitute except in pain control, which was marginally less for the treatment for recurrent apthous stomatitis (minor).


How to cite this article:
Shrivastava K, Naidu G, Deshpande A, Handa H, Raghuvanshi V, Gupta M. Comparative evaluation of the efficacy of topical amlexanox 5% oral paste and triamcinolone acetonide 0.1% oral paste in the treatment of Recurrent Aphthous Stomatitis (RAS).J Indian Acad Oral Med Radiol 2018;30:235-240


How to cite this URL:
Shrivastava K, Naidu G, Deshpande A, Handa H, Raghuvanshi V, Gupta M. Comparative evaluation of the efficacy of topical amlexanox 5% oral paste and triamcinolone acetonide 0.1% oral paste in the treatment of Recurrent Aphthous Stomatitis (RAS). J Indian Acad Oral Med Radiol [serial online] 2018 [cited 2021 Nov 29 ];30:235-240
Available from: https://www.jiaomr.in/article.asp?issn=0972-1363;year=2018;volume=30;issue=3;spage=235;epage=240;aulast=Shrivastava;type=0