Journal of Indian Academy of Oral Medicine and Radiology

REVIEW ARTICLE
Year
: 2014  |  Volume : 26  |  Issue : 1  |  Page : 55--61

Steroid sparing regimens for management of oral immune-mediated diseases


Arti Agrawal, Mariappan Jonathan Daniel, Subramanian Vasudevan Srinivasan, Vannathan Kumaran Jimsha 
 Department of Oral Medicine and Radiology, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Pondicherry, Puducherry (UT), India

Correspondence Address:
Arti Agrawal
Department of Oral Medicine and Radiology, Mahatma Gandhi Postgraduate Institute of Dental Sciences, Pondicherry, Puducherry (UT)
India

Immune-mediated mucocutaneous disease may present oral symptoms as a first sign of the disease. The primary etiology could be the cellular and/or humoral immune responses directed against epithelial or connective tissue, in a chronic and recurrent pattern. Lichen planus, pemphigus vulgaris and bullous pemphigoid are the most frequent immunologically mediated mucocutaneous diseases. More often than not, patients present with complaints of blisters, oral ulcers, pain, burning sensation, and bleeding from the various oral sites. Steroids, whether topical or systemic, are the treatment of choice as they have both anti-inflammatory and immune-suppressant properties; however, challenges in the treatment of autoimmune diseases are the complexity of symptoms, the need to manage long-term medications for preserving organ function, and the long-term adverse effects of steroids. In such situations steroid sparing agents, such as, tacrolimus, dapsone, azathioprine, cyclosporine, and so on, may be helpful. Here an attempt is made to review various treatment regimens that could be used as alternatives to steroids for management of such diseases.


How to cite this article:
Agrawal A, Daniel MJ, Srinivasan SV, Jimsha VK. Steroid sparing regimens for management of oral immune-mediated diseases .J Indian Acad Oral Med Radiol 2014;26:55-61


How to cite this URL:
Agrawal A, Daniel MJ, Srinivasan SV, Jimsha VK. Steroid sparing regimens for management of oral immune-mediated diseases . J Indian Acad Oral Med Radiol [serial online] 2014 [cited 2021 Mar 2 ];26:55-61
Available from: https://www.jiaomr.in/article.asp?issn=0972-1363;year=2014;volume=26;issue=1;spage=55;epage=61;aulast=Agrawal;type=0