Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Subscribe Search Contacts Login 
  • Users Online: 6763
  • Home
  • Print this page
  • Email this page

 Table of Contents  
Year : 2018  |  Volume : 30  |  Issue : 1  |  Page : 68-72

Nikolsky's sign - A clinical method to evaluate damage at epidermal-dermal junction

Department of Oral Medicine and Radiology, Modern Dental College and Research Center, Indore, Madhya Pradesh, India

Date of Submission05-Oct-2017
Date of Acceptance04-Mar-2018
Date of Web Publication23-Apr-2018

Correspondence Address:
Dr. Abhishek G Soni
Department of Oral Medicine and Radiology, Modern Dental College and Research Center, Indore - 453 112, Madhya Pradesh
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jiaomr.jiaomr_95_17

Rights and Permissions

Soft tissues of the oral cavity are often affected by various mucocutaneous disorders of variable etiology, affecting both the skin and mucosae, with severe clinical manifestations such as blisters involving the tissues; and therefore their appropriate management relies on their correct diagnosis. Clinical signs to elicit characteristics of blisters are a crucial part of the examination of patients with such disorders. It is therefore essential for clinicians to be familiar with, or rather be expert at eliciting these signs to frame an accurate diagnosis, since proper treatment and follow-up will depend on which disease is involved. The Nikolsky's sign is one such sign that can be helpful in the clinical diagnosis of pemphigus group of disease and differentiating it from other blistering dermatoses. This review gives an overview of sign of Nikolsky and other related sign, its clinical presentation and their diagnostic implications, using PubMed and Medline databases searching for articles written in English. Peer-reviewed articles were targeted using the keywords “Nikolsky's sign”, “mucocutaneous disorders” and “pemphigus”. Available full-text articles were read, and related articles were also scrutinized and finally the search was subsequently refined to articles concerning to “Nikolsky's sign”. It was concluded that early recognition of these signs are necessary to prevent delayed diagnosis and for early institution of appropriate treatment of these potentially serious mucosal and dermatological diseases.

Keywords: Dermis, epidermis, mucocutaneous disorders, Nikolsky's sign, pemphigus

How to cite this article:
Soni AG. Nikolsky's sign - A clinical method to evaluate damage at epidermal-dermal junction. J Indian Acad Oral Med Radiol 2018;30:68-72

How to cite this URL:
Soni AG. Nikolsky's sign - A clinical method to evaluate damage at epidermal-dermal junction. J Indian Acad Oral Med Radiol [serial online] 2018 [cited 2022 Dec 4];30:68-72. Available from: http://www.jiaomr.in/text.asp?2018/30/1/68/230902

   Introduction Top

The autoimmune mucocutaneous disorders are the group of diseases, sometimes characterized by acantholysis and in which components of the epidermis and basement membrane zone are targeted resulting in the formation of mucosal and cutaneous blisters.[1] Clinical identification of these blisters are necessary to interpret the pathology accurately. Clinical signs are the well-known mechanical signs evolved by clinicians and are considered an important part of clinical examination in patient with these disorders. The Nikolsky's sign is defined as a well-described clinical sign which manifest as dislodgement of intact superficial epidermis by a shearing force, indicating a plane of cleavage in the epidermis. The defect may be due to epidermal antibodies as in pemphigus or staphylococcal toxin as in staphylococcal scalded skin syndrome.[2] It is characteristically associated with pemphigus vulgaris.[3] The presence of Nikolsky's sign is a significant indicator of active acantholysis and altered structural integrity within the epidermis,[4] which allows a physician to determine the level of the split in the skin so as to distinguish between intraepidermal and subepidermal blistering diseases in the clinical settings.[5],[6],[7]

Literature often covers clinical observations and individual case reports in relation to these diseases but little attention has been paid to the importance and clinical utility of Nikolsky's sign and other related sign in the diagnosis of these disorders. This clinical paper is an attempt to illustrate the usefulness of Nikolsky's sign and other related signs along with their diagnostic and prognostic significance in the clinical diagnosis of various mucocutaneous blistering diseases affecting the skin and oral cavity.

   Methods Top

To get up-to-date information, a web-based search was initiated using PubMed/Medline database searching for articles written in English. Peer-reviewed articles were targeted using the key terms “Nikolsky's sign”, “mucocutaneous disorders” and “pemphigus” to determine the scope of coverage in well-documented articles. The search was subsequently refined to articles concerning to “Nikolsky's sign”. The sites of specialized scientific journals in the areas of oral and maxillofacial pathology, dermatology, and other relevant journals were also used. The bibliographies were also reviewed to identify additional relevant studies. Available full-text articles were read, and related articles were also scrutinized.

Historical Perspective

Nikolsky's sign was first described by a Russian dermatologist, Piotr Vasiliyevich Nikolsky (1858-1940).[5] Although his name was spelt Nikolskiy, the sign is better known as Nikolsky's sign.[8] He related how, after rubbing the skin of patients who had pemphigus foliaceus, there was a blistering or denudation of the epidermis with a glistening, moist surface underneath.[9] According to his explanation, the skin showed a weak relationship and contact among the epidermal layers (between the corneal and granular cell layers) on all surfaces and even in places between lesions (e.g., blisters and excoriations) on seemingly unaffected skin.[10]

The credit of the finding “Nikolsky's sign” should also go to his teacher Professor M.I. Stukovenkov [(a Russian Dermatologist (1847-1897), at the University of Kiev)] who pointed out this observation in pemphigus foliaceus. However, the sign was well described by P.V. Nikolskiy in his thesis and popularly came to be known as Nikolsky's sign. Nikolsky's observations were later confirmed by Lyell in 1956, who described a Nikolsky's sign in patients with toxic epidermal necrolysis.[9]


The pathophysiology associated with Nikolsky's sign is the acantholysis [8] i.e., loss of coherence between epidermal cells due to the breakdown of their intercellular bridges.[11],[12],[13] In acantholysis, the cells remain intact but are no longer attached to each other; they tend to acquire the smallest possible surface area and become rounded up, resulting in intra-epidermal clefts, vesicles and bullae.[11] The sign can be elicited in the affected areas as well as in areas with intact, normal-appearing skin and also on the oral mucosal surface.[8],[14] However, in the oral cavity identification of intact vesicle and bulla really posed challenge to the clinician because of friable nature of oral mucosa and also due to the constant exposure of oral mucosa to the frictional irritation. Furthermore, rupture of these lesions leads to erosions or ulcerations on the mucosal surface, hence making the diagnosis of such lesions even more difficult because the lesions often resemble each other clinically and sometimes it is difficult to differentiate between them. The primary histologic finding in patients with pemphigus is acantholysis with the occurrence of suprabasal epidermal/intraepidermal splits;[15],[16] these events presumably contribute to the epidermal separation characteristic of a positive Nikolsky's sign.[7] Nikolsky's sign is usually positive in diseases with intraepidermal acantholysis and typically negative in diseases with dermo-epidermal separation,[8] thus helping to distinguish pemphigus from bullous pemphigoid.[7]

Elicitation of Nikolsky's sign

Till today there is no absolute consensus available in the literature on a standard method to elicit the Nikolsky's sign. However, Nikolskiy originally described three methods to elicit the sign:[5],[15],[17]

  1. Horny layer can be detached for a long distance, even on normal-appearing skin, by pulling a remnant of the ruptured wall of the blister;
  2. Horny layer can be dislodged on visibly normal skin areas at the periphery of existing lesions by lateral pressure with a finger; and
  3. Normal-appearing skin can be denuded leaving the moist surface of the granular layer by rubbing the epidermis.

Although the classic Nikolsky's sign is seen on the skin, there have been two case reports showing its appearance on mucous membranes of other tissues. In one instance, a Nikolsky's sign was elicited in the esophageal mucosa of a patient with pemphigus vulgaris.[18] In the other, Nikolsky's sign was elicited in the mucosa of the uterine cervix in 13 of 16 patients with pemphigus.[19] However, these occurrences are exceedingly rare.

Conditions associated with Nikolsky's sign

Positive Nikolsky's sign is the hallmark of pemphigus vulgaris,[4] and is helpful in the clinical diagnosis of pemphigus group of diseases.[15] Uzun and Durdu [5] in their study on 123 consecutive patients with various cutaneous diseases presenting as intact blisters and/or erosions concluded that Nikolsky ' s sign offers a moderately sensitive but highly specific tool for the diagnosis of pemphigus. Other blistering conditions, which are known to exhibit Nikolsky's sign include pemphigus foliaceous, paraneoplastic pemphigus,  Stevens-Johnson syndrome More Details, staphylococcal scalded skin syndrome (SSSS), toxic epidermal necrolysis (TEN), oral lichen planus, benign mucous membrane pemphigoid, and epidermolysis bullosa.[20],[21]

Variants of Nikolsky's sign

Clinical Nikolsky's sign

When the tangential pressure is applied on apparently normal skin/mucosa, or on peri-lesional skin/mucosa or on affected skin/mucosa with the thumb or fingerpad result is a shearing force that dislodges the upper layers of epidermis from the lower epidermis resulting in formation of blisters, a phenomenon is known as Nikolsky's sign (Clinical Nikolsky's sign).[4],[6],[10],[15],[17],[22]

Microscopic Nikolsky's sign

Microscopic Nikolsky's sign is the subclinical counterpart of Nikolsky's sign.[11] When tangential pressure is exerted on apparently normal skin/mucosa, same as in eliciting clinical Nikolsky's sign, result in weakening of the intercellular adhesion. This may produce minimal damage at the cellular level which can be demonstrated only microscopically. The pathological changes that are induced after applying tearing tangential pressure to skin/mucosa at the subclinical level, is defined as microscopic Nikolsky's sign.[4],[11],[16]

It has been proposed that microscopic Nikolsky's sign may be a better and more sensitive method of rapid diagnosis and can increase the sensitivity of the histopathological studies.[18] Hameed and Khan [16] in their study demonstrated a positive microscopic Nikolsky's sign in 73.9% of pemphigus patients who were biopsied after applying tangential pressure. There were no changes in the biopsies of healthy controls. They suggested that this technique could be of value in areas where immunofluorescence is not readily available. In another study by Barzegari M et al.,[4] they suggested that microscopic Nikolsky's sign was significantly higher in patients with generalized disease. Pemphigus vulgaris patients with mucocutaneous involvement have both desmoglein (Dsg3) and Dsg1 antibodies.[23],[24] Presence of the generalized disease is probably due to much higher pemphigus antibody levels, making the development of microscopic Nikolsky's sign more frequent. Thus they concluded that microscopic Nikolsky's sign can increase the sensitivity of histologic diagnosis of pemphigus vulgaris.[4]

Marginal and Direct Nikolsky's sign

“Marginal Nikolsky's sign” can be described as the extension of the erosion on the surrounding normal-appearing skin by rubbing the skin surrounding existing lesions; while “Direct Nikolsky's sign” is the induction of an erosion on normal-appearing skin, distant from the lesions.[6],[11] A positive direct Nikolsky's sign indicates severe activity of the disease in pemphigus. It is the first sign to disappear as the disease responds to therapy; the marginal Nikolsky's sign may persist for sometime.[25]

Uzun and Durdu [5] determine the usefulness of the Nikolsky's sign on the clinical diagnosis of pemphigus in 123 consecutive patients and found that the sensitivity of “direct” Nikolsky's sign (38.4%) was less than that of the “marginal” form (69.2%), but the specificity of “direct” Nikolsky's sign (100%) was higher than that of the “marginal” form (93.8%). Based on the result of the study they concluded that a positive Nikolsky's sign, when elicited especially with ''direct'' modification, is moderately sensitive but highly specific for clinical diagnosis of pemphigus, particularly for pemphigus vulgaris.

Wet and Dry Nikolsky's sign

Nikolsky's sign is further characterized as “wet” and “dry”. After applying pressure on the skin or oral mucosal surface, when the eroded base is found to be moist and glistening, the Nikolsky's sign is considered as “wet”; while “dry” Nikolsky's sign can be described as those, in which the base of eroded skin or oral mucosal surface is dry.[7],[11]

Modified Nikolsky's sign

The “modified Nikolsky's” sign is described as the peripheral extension of blisters on applying pressure to their surface. This is helpful in patients in whom a new vesicle or bulla is not available for biopsy. The advantage here is that the artificially extended blister cannot show epithelial regeneration, which is sometimes seen in the floor of older subepidermal blisters making them appear as intraepidermal.[25],[26],[27]

Implications of Nikolsky's sign

Diagnostic implication

  • Nikolsky's sign is pathognomonic of pemphigus and can be used as a preliminary test for the clinical diagnosis of pemphigus in clinical settings. Although questions have been raised about its sensitivity and specificity,[28],[29] it appears to be a highly specific technique in the oral setting (96.3%) and may be very useful in the fundamental diagnosis of oral blistering diseases.[30] Although the Nikolsky's sign is highly specific, it only offers moderate sensitivity for the diagnosis of pemphigus vulgaris [5]
  • Nikolsky's sign is also useful in differentiating various blistering diseases. It is usually positive in intraepidermal blistering disease while in subepidermal blistering disease such as bullous pemphigoid, the sign is usually absent.[7]

Prognostic implication

  • Nikolsky's sign may also be considered as a suggestive sign for the prognosis of pemphigus by indicating active disease or clinical exacerbation.[5] The Nikolsky's sign is positive in the active or progressive stage of pemphigus. It becomes negative when patient receives immunosuppressive therapy and it indicates the end of acute stage disease. However, its reappearance during the course of treatment signals a flare up. Such a patient would require an increase in the dosage of immunosuppressant or the introduction of new drugs [25]
  • In patients with active pemphigus vulgaris, a wet sign is expected, whereas the dry sign indicates re-epithelialization beneath a pemphigus blister which would signifying healing and thus a favorable finding.[21]

Nikolsky's phenomenon

The term “Nikolsky's phenomenon” is applied when the superficial layer of the epidermis is felt to move over the deeper layer, and instead of immediately forming erosion as in Nikolsky's sign, a blister develops after some time.[25]

Mauserung phenomenon

The Nikolsky's sign may also be elicitable in the rare ichthyosis bullosa of Siemens, where it is termed the “Mauserung phenomenon”.[31]

False Nikolsky's sign

False Nikolsky's sign, also known as Sheklakov's sign, is described as pulling the peripheral remnant roof of a ruptured blister, thereby extending the erosion on the surrounding normal skin. The erosions thus induced are limited in size, lack the tendency to extend spontaneously, and heal rapidly.[11],[25] It is called the “false Nikolsky's sign” because it is a subepidermal cleavage occurring in the perilesional skin.[6]

False Nikolsky's sign is positive in sub-epidermal blistering disorders that includes bullous pemphigoid, cicatricial pemphigoid, pemphigoid gestationis, dermatitis herpetiformis, linear immunoglobulin A (IgA) bullous dermatosis, epidermolysis bullosa acquisita, junctional and dystrophic epidermolysis bullosa, porphyrias and bullous systemic lupus erythematosus (SLE).[25]

Pseudo Nikolsky's sign

Pseudo Nikolsky's sign or epidermal peeling sign can be elicited in the same way as for true Nikolsky's sign, but this could be elicited only in the involved erythematous areas. Here, the underlying mechanism is necrosis of epidermal cells in contrast to acantholysis in true Nikolsky's sign.[11],[14],[25]

Pseudo Nikolsky's sign is positive in Stevens-Johnson syndrome, toxic epidermal necrolysis, in some cases of burns and bullous ichthyosiform erythroderma.[25]

Other related signs

Bulla spread sign

The “bulla spread sign”, also known as Lutz sign,[14],[25] refers to the extension of a blister to adjacent unblistered skin when pressure is put on the top of the bulla.[32]

In the traditional “bulla spread” sign, the margin of an intact bulla is first marked by a pen. Slow and careful unidirectional pressure applied by a finger to the bulla causes peripheral extension of the bulla beyond the marked margin. The bulla thus extended has an irregular angulated border in pemphigus vulgaris, while a regular rounded border is observed in bullous pemphigoid or other subepidermal blistering disorders. The sign may also be elicited on a burst blister if an adequate portion of the roof is intact.[14],[25]

The bulla spread sign is positive in all varieties of blistering diseases like the pemphigus group of diseases and many cases of subepidermal blisters, including bullous pemphigoid, dermatitis herpetiformis, epidermolysis bullosa acquisita, cicatricial pemphigoid, dystrophic epidermolysis bullosa, bullous drug eruptions, Stevens-Johnson syndrome and toxic epidermal necrolysis.[14],[25]

Asboe-Hansen sign

The Asboe-Hansen sign, named by a Danish physician, Gustav Asboe-Hansen (1917-1989),[14],[33] is considered as a variation of the bulla spread sign. However, it applies to smaller, intact, tense bullae where the pressure is applied to the centre of the blister.[34]

Both Asboe Hansen and Nikolsky's sign have been demonstrated in acute bullous lichen planus.[35] Due to fragility of the roof of the blister Asboe Hansen sign is usually negative in  Hailey-Hailey disease More Details and staphylococcal scalded skin syndrome.[25]

   Conclusion Top

Despite the numerous investigation methods that are used in the diagnosis of autoimmune blistering diseases, Nikolsky's sign, if performed correctly and interpreted properly, can still serve as a useful and rapid diagnostic tool to assist in preliminary chairside diagnosis of the pemphigus group of disease and also differentiating it from other blistering diseases. Also, in those areas where facilities for immunofluorescence are limited and appropriate lesions for obtaining meaningful results by routine histopathology are not readily available, these clinical signs could be used as an adjunctive diagnostic measure. In summary, it appears reasonable to conclude that every clinician should be aware about these clinical signs which are imperative in early diagnosis and prompt treatment of these potentially fatal mucocutaneous diseases in clinical settings. Although the lack of standardization regarding how exactly to elicit the sign has limited its usefulness, but it remains an interesting sign to observe and interpret.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Sawant P, Kshar A, Byakodi R, Paranjpe A. Immunofluorescence in oral mucosal diseases-a review. Oral Surg Oral Med Oral Radiol 2014;2:6-10.  Back to cited text no. 1
Moss C, Gupta E. The Nikolsky sign in staphylococcal scalded skin syndrome. Arch Dis Child 1998;79:290.  Back to cited text no. 2
Rastogi V, Sharma R, Misra SR, Yadav L. Diagnostic procedures for autoimmune vesiculobullous diseases: A review. J Oral Maxillofac Pathol 2014;18:390-7.  Back to cited text no. 3
[PUBMED]  [Full text]  
Barzegari M, Valikhani M, Esmaili N, Naraghi Z, Nikoo A, Kamyab K, et al. Microscopic Nikolsky's sign: Is it useful for diagnosis of pemphigus vulgaris?. Iran J Dermatol 2008;11(2):64-6.,8.  Back to cited text no. 4
Uzun S, Durdu M. The specificity and sensitivity of Nikolsky sign in the diagnosis of pemphigus. J Am Acad Dermatol. 2006;54(3):411-5.  Back to cited text no. 5
Grando SA, Grando AA, Glukhenky BT, Doguzov V, Nguyen VT, Holubar K. History and clinical significance of mechanical symptoms in blistering dermatoses: A reappraisal. J Am Acad Dermatol 2003;48:86-92.  Back to cited text no. 6
Urbano FL. Nikolsky's sign in autoimmune skin disorders. Hosp Physician 2001;37:23-4.  Back to cited text no. 7
Channual J, Wu JJ. The Nikolskiy sign. Arch Dermatol 2008;144:1140.  Back to cited text no. 8
Arndt KA, Feingold DS. The sign of Pyotr Vasilyewich Nikolsky. N Engl J Med 1970;282:1154-5.  Back to cited text no. 9
Goodman H. Nikolsky sign; page from notable contributors to the knowledge of dermatology. AMA Arch Derm Syphilol 1953;68:334-5.  Back to cited text no. 10
Seshadri D, Kumaran MS, Kanwar AJ. Acantholysis revisited: Back to basics. Indian J Dermatol Venereol Leprol 2013;79:120-6.  Back to cited text no. 11
[PUBMED]  [Full text]  
Young S, Jee SH, Chang CH. Mal de Meleda with incidental acantholysis - a case report with histopathological and ultrastructural studies. Dermatol Sinica 1997;15:87-92.  Back to cited text no. 12
Mihm MC, Kibbi AG, Klaus Wolff. Basic pathologic reactions of the skin. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest B, Paller AS, Leffell DJ, editors. Fitzpatrick's Dermatology In General Medicine. 7th ed. New York: McGraw-Hill; 2008. p. 45-7.  Back to cited text no. 13
Ganapati S. Eponymous dermatological signs in bullous dermatoses. Indian J Dermatol 2014;59:21-3.  Back to cited text no. 14
[PUBMED]  [Full text]  
Polifka M, Krusinski PA. The Nikolsky sign. Cutis 1980;26:521-5,526.  Back to cited text no. 15
Hameed A, Khan AA. Microscopic Nikolsky's sign. Clin Exp Dermatol 1999;24:312-4.  Back to cited text no. 16
Doubleday CW. Who is Nikolsky and what does his sign mean? J Am Acad Dermatol 1987;16:1054-5.  Back to cited text no. 17
Coelho LK, Troncon LE, Roselino AM, Campos MS, Módena JL. Esophageal Nikolsky's sign in pemphigus vulgaris. Endoscopy. 1997;29:S35.  Back to cited text no. 18
Sagher F, Bercovici B, Romem R. Nikolsky sign on cervix uteri in pemphigus. Br J Dermatol 1974;90:407-11.  Back to cited text no. 19
Goldberg SH, Bronson D. Blistering diseases. Diagnostic help for primary care physicians. Postgrad Med 1991;89:159-62.  Back to cited text no. 20
Salopek TG. Nikolsky's sign: is it 'dry' or is it 'wet'? Br J Dermatol 1997;136:762-7.  Back to cited text no. 21
Stanley JR. Pemphigus. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitzpatrick's Dermatology in general medicine. 5th ed. New York: McGraw-Hill; 1999. p. 657-66.  Back to cited text no. 22
Amagai M, Tsunoda K, Zillikens D, Nagai T, Nishikawa T. The clinical phenotype of pemphigus is defined by the antidesmoglein autoantibody profile. J Am Acad Dermatol 1999;40:167-70.  Back to cited text no. 23
Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Gamou S, et al. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. J Immunol 1997;159:2010-7.  Back to cited text no. 24
Sachdev D. Sign of Nikolskiy and related signs. Indian J Dermatol Venereol Leprol 2003;69:243-4.  Back to cited text no. 25
Baxter DL. Vesicobullous diseases. In: Demis DJ, editor. Clinical dermatology. Philadelphia: Harper and Row; 1975. p. 6-1:1-5.  Back to cited text no. 26
Cohen LM, Skopicki DK, Harrist TJ, Clark Jr WH. Noninfectious vesiculobullous and vesiculopustular diseases. In: Lever's Histopathology of skin. 8th ed. Philadelphia: Lippincott-Raven; 1997. p. 209-52.  Back to cited text no. 27
Ruocco E, Baroni A, Wolf R, Ruocco V. Life-threatening bullous dermatoses: Pemphigus vulgaris. Clin Dermatol 2005;23:223-6.  Back to cited text no. 28
Scully C, Mignogna M. Oral mucosal disease: Pemphigus. Br J Oral Maxillofac Surg 2008;46:272-7.  Back to cited text no. 29
Mignogna MD, Fortuna G, Leuci S, Ruoppo E, Marasca F, Matarasso S. Nikolsky's sign on the gingival mucosa: A clinical tool for oral health practitioners. J Periodontol 2008;79:2241-6.  Back to cited text no. 30
Griffiths WAD, Judge MR, Leigh IM. Disorders of keratinisation. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Rook Textbook of dermatology. 6th ed. London: Blackwell Science; 1998. p. 1483-588.  Back to cited text no. 31
James WD, Berger TG, Elston DM. Chronic blistering dermatoses. In: James WD, Berger TG, Elston DM, editors. Andrews' Diseases of the Skin Clinical Dermatology. 10th ed. Philadelphia: Saunders; 2005. p. 459-78.  Back to cited text no. 32
Bartolucci SL. Stedman's Medical Eponyms. 2nd ed. Philadelphia: Lippincott, Williams & Wilkins; 2005. p. 29.  Back to cited text no. 33
Odom RB, James WD, Berger TG. Cutaneous lymphoid hyperplasia, cutaneous T-cell lymphoma, other malignant lymphomas, and allied diseases. In: Andrews' Diseases of the Skin: Clinical Dermatology. 9th ed. Philadelphia: WB Saunders; 2000.p. 918-42.  Back to cited text no. 34
Kaur S, Singh M, Radotra BD, Sehgal S. Positive Nikolsky's and bulla-spread signs in acute bullous lichen planus. Arch Dermatol 1987;123:1122-3.  Back to cited text no. 35

This article has been cited by
1 Stevens-Johnson syndrome linked to tramadol use and ultraviolet radiation
Blake J. McKinley, J. Scott Parkinson
Medicine: Case Reports and Study Protocols. 2021; 2(12): e0176
[Pubmed] | [DOI]
2 Clinical clues predictive of Stevens-Johnson syndrome as the cause of chronic cicatrising conjunctivitis
Swapna S Shanbhag, Sanjay Chanda, Pragnya Rao Donthineni, Sayali Sanjeev Sane, Smruti Rekha Priyadarshini, Sayan Basu
British Journal of Ophthalmology. 2020; 104(7): 1005
[Pubmed] | [DOI]
3 A simple and succinct simulation of Nikolsky phenomenon and sign
KeshavmurthyA Adya, ArunC Inamadar, Aparna Palit
Indian Dermatology Online Journal. 2020; 11(3): 465
[Pubmed] | [DOI]


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

   Abstract Introduction Methods Conclusion
  In this article

 Article Access Statistics
    PDF Downloaded2703    
    Comments [Add]    
    Cited by others 3    

Recommend this journal