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ORIGINAL ARTICLE
Year : 2016  |  Volume : 28  |  Issue : 4  |  Page : 375-380

Lipid profile in patients with oral submucous fibrosis, lichen planus, and leukoplakia


1 Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Center, Hyderabad, Telangana, India
2 Department of Oral Medicine and Radiology, People's Dental College, Bhopal, Madhya Pradesh, India
3 Department of Oral Medicine and Radiology, Dnyandeo Yashwantrao Patil Dental College and Hospital, Pune, Maharashtra, India

Correspondence Address:
Dr. Mamatha Boringi
Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Center, Hyderabad, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jiaomr.JIAOMR_127_15

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Introduction: Lipids are essential for various biological functions, including cell growth and division of normal and malignant tissues. Changes in the lipid profile have long been associated with malignancies. Aims: The aim of this study was to evaluate the alterations in lipid profile in patients with oral submucous fibrosis (OSMF), leukoplakia and lichen planus. Materials and Methods: This is a hospital-based study conducted among a total of 80 patients; 20 patients in the control group and 20 patients with histopathologically confirmed cases of OSMF, leukoplakia, and lichen planus group. Serum cholesterol, triglyceride, low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) and Apo A1were analyzed among the included patients. Statistical Analysis Used: Analysis of variance and post hoc tests were performed. Results: Serum total cholesterol, HDL and Apo A1levels were significantly decreased in OSMF patients, and HDL and Apo A1levels were also significantly decreased in leukoplakia patients. There was no difference in lipid profiles in lichen planus patients. Conclusions: The findings of the present study warrant in depth investigation of lipids and their mechanism of transportation through cell membranes as well as the role of receptors in maintaining cell integrity and their association with different precancerous lesions and conditions.


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