Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Subscribe Search Contacts Login 
  • Users Online: 1095
  • Home
  • Print this page
  • Email this page
CASE REPORT
Year : 2012  |  Volume : 24  |  Issue : 2  |  Page : 158-161

Cleidocranial dysplasia in son and father: Report of two rare cases with review of literature


1 Professor, Department of Oral Medicine and Radiology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India
2 Reader, Department of Oral Medicine and Radiology, Sri Venkateswara Dental College, Thalambur, Chennai, Tamil Nadu, India
3 Senior Lecturer. Department of Oral Medicine and Radiology, Ragas Dental College and Hospital. Chennai, Tamil Nadu, India
4 Professor and Head, Department of Oral Medicine and Radiology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
Chandra Mouli
Reader, Department of Oral Medicine and Radiology, Sri Venkateswara Dental College, Thalambur, Chennai, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.5005/jp-journals-10011-1285

Rights and Permissions

Cleidocranial dysplasia (CCD) is a rare autosomal dominant skeletal disease, which is caused by mutation in the gene on 6p21 encoding transcription factor CBFA1, i.e runt-related transcription factor 2 (RUNX2). The disease is characterized by a persistently open anterior fontanelle and skull sutures, hypoplastic or aplastic clavicles, dental abnormalities, short stature, a wide pubic symphysis and a variety of other skeletal changes. A major finding of CCD is hypoplasia or aplasia of clavicular bones resulting in the ability of the patient to approximate the shoulders. Delayed closure of the anterior fontanelle and of metopic sutures causes frontal bossing. We report a rare case of CCD in a 15-year-old boy and in his father and emphasize the importance of clinical and radiographic findings in CCD.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed199    
    Printed2    
    Emailed0    
    PDF Downloaded56    
    Comments [Add]    

Recommend this journal