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REVIEW ARTICLE
Year : 2012  |  Volume : 24  |  Issue : 2  |  Page : 142-145

Role of defensins in oral diseases: An overview


1 Professor, Department of Periodontics. Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh, India
2 Professor and Head, Department of Oral Medicine and Radiology Shree Bankey Bihari Dental College and Research Centre Ghaziabad, Uttar Pradesh, India
3 Senior Lecturer, Department of Oral Medicine and Radiology Shree Bankey Bihari Dental College and Research Centre Ghaziabad, Uttar Pradesh, India

Correspondence Address:
Sharanamma B Bhagawati
Professor, Department of Periodontics. Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.5005/jp-journals-10011-1280

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The oral cavity outreaches as a particular environment in which there is a continuous interplay between bacteria, fungi and viruses and the epithelial barrier. Among the innate mechanisms that aim to establish a regulated equilibrium between health and disease, natural antimicrobial peptides, especially those part of the defensins' family, have emerged as fundamental mediators. Their biological role is emphasized by the large number of expressed genes as well as the multiplicity of the individual molecules present on biological tissues and fluids, in physiological and pathological conditions. Furthermore, the direct antimicrobial action, defensins may play a pivotal role in the orchestration of the innate response and contribute to the interplay between the innate and adaptive immunity. This review focuses on the specificities of defensins.


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