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RESEARCH
Year : 2012  |  Volume : 24  |  Issue : 2  |  Page : 102-105

Genetic damage in exfoliated cells from oral mucosa of individuals exposed to x-rays after panoramic radiograph: A cross-sectional study


1 Lecturer, Department of Oral Medicine and Radiology Sri Venkateshwara Dental College, Chennai, Tamil Nadu, India
2 Reader, Department of Prosthodontics, Sri Venkateshwara Dental College, Chennai, Tamil Nadu, India
3 Professor and Head, Department of Oral Medicine and Radiology Ragas Dental College and Hospital, Chennai, Tamil Nadu, India
4 Professor, Department of Oral Medicine and Radiology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
Ramalakshmi Madhavan
Lecturer, Department of Oral Medicine and Radiology Sri Venkateshwara Dental College, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.5005/jp-journals-10011-1271

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Objectives: In the past decades, X-rays have been used widely for diagnosis in dentistry. However, it is well known that ionizing radiation causes damage (including single- and double-strand breaks) to deoxyribonucleic acid (DNA) and DNA-protein crosslinks, and induces cellular death. Therefore, outlining the cytogenetic effects induced by X-ray is necessary to identify the degree of cancer risk and minimize potential risks to patients and clinicians. Materials and methods: Cytogenetic biomonitonng studies focusing on oral mucosa cells in individuals exposed to dental X-ray were reviewed. Results: Dental X-ray can induce DNA damage and cytotoxicity in oral mucosa cells. Conclusion: These results will contribute to a better understanding of X-ray-induced effects upon the cellular system in individuals continually exposed to known genotoxic/cytotoxic agents.


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