Oxcarbazepine: Drug of the future in the treatment of trigeminal neuralgia

Revant H Chole; Ranjitkumar N Patil; Swati V Balsaraf; Shailesh M Gondivkar; Amol Gadbail

doi:10.5005/jp-journals-10011-1164

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RESEARCH ARTICLE

Year : 2011 | Volume : 23 | Issue : 5 | Page : 340-343

Oxcarbazepine: Drug of the future in the treatment of trigeminal neuralgia

Revant H Chole¹, Ranjitkumar N Patil², Swati V Balsaraf³, Shailesh M Gondivkar⁴, Amol Gadbail⁵
¹ Reader, Department of Oral Medicine and Radiology, Modern Dental College, Indore, Madhya Pradesh, India
² Professor and Head, Department of Oral Medicine and Radiology, King George Medical College, Lucknow, Uttar Pradesh, India
³ Department of Public Health Dentistry, People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India
⁴ Senior Lecturer, Department of Oral Medicine and Radiology, MGVs KBH Dental College and Hospital, Nashik, Maharashtra, India
⁵ Senior Lecturer, Department of Oral Pathology and Microbiology, SP Dental College, Wardha, Maharashtra, India

Correspondence Address:
Revant H Chole
Reader, Department of Oral Medicine and Radiology, Modern Dental College Indore-453112, Madhya Pradesh
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.5005/jp-journals-10011-1164

Background: The aim of the study was to estimate the efficacy of oxcarbazepine in trigeminal neuralgia. Oxcarbazepine is a novel antiepilepfic drug, and its effect on trigeminal neuralgia has not been studied extensively previously. Materials and methods: Fifty-three patients with trigeminal neuralgia (34 men and 19 women) took a mean dose of 600 mg of oxcarbazepine for a period of three weeks. Pain intensity was measured by using visual analog scale. Results: Of the 53 patients, 42 (79%) were completely or well controlled by OXC, and nine (17%) partially but acceptably controlled. Treatment with OXC was therefore satisfactory initially in 51 (96%) of the patients. In seven of these patients, mild transient side effects occurred but did not necessitate cessation of treatment Conclusion: OXC appears to be an effective substitute for carbamazepine in those patients intolerant of this agent, or experiencing significant side effects.

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