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Year : 2020  |  Volume : 32  |  Issue : 1  |  Page : 50-54

Medication-related osteonecrosis of the jaw: A review about etiology, risk factors, pathophysiology, and treatment

Department of Oral Medicine and Radiology, Government College of Dentistry, Indore, Madhya Pradesh, India

Correspondence Address:
Dr. Sheetal Singar
Shangrila 6, Shri Krishna Nagar, Airport Road in Front of BSF Campus, Indore, Madhya Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jiaomr.jiaomr_206_19

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Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of antiresorptive and antiangiogenic medication. MRONJ is considered when a patient has exposed bone in the jaw for more than 8 weeks and has a history of antiresorptive and antiangiogenic medication with a negative history of radiotherapy. Antiresorptive and antiangiogenic medication do not independently cause necrosis of bone. Various systemic and local risk factors like dentoalveolar trauma and extraction play an important role in the development of MRONJ. MRONJ can be prevented by proper dental evaluation and by performing the required treatment before commencing antiresorptive and antiangiogenic medication.

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