Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Subscribe Search Contacts Login 
  • Users Online: 577
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 30  |  Issue : 4  |  Page : 367-371

Evaluation of human papillomavirus as an independent risk factor in known patients of oral squamous cell carcinoma using immunohistochemistry


1 Department of Oral Medicine and Radiology, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, India
2 Department of Oral Medicine and Radiology, Saraswati Dental College, Lucknow, Uttar Pradesh, India
3 Department of Dentistry, Saraswati Medical College, Unnao, Uttar Pradesh, India

Correspondence Address:
Dr. Siddharth K Singh
Department of Oral Medicine and Radiology, Saraswati Dental College, 233 Tiwari Ganj, Faizabad Road, Lucknow, Uttar Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jiaomr.jiaomr_122_18

Rights and Permissions

Introduction: Oral cancer (OC), ever since its discovery has not failed to claim lives of many. However, in between 1960s and 1980s, some astonishing trends started to emerge pertaining to OC, which almost entirely changed the face of this ailment. Almost a fourfold ascent in the number of patients diagnosed with OC was seen in the age group of 30–39 years! Authors, after several studies and meticulous observations got a clear picture of the phenomenal changes. These changes, which were almost entirely attributed to a rise of human papillomavirus (HPV) after few years became a global issue and did not leave Asian countries, including India unscathed. Rigorous studies were conducted in India, although each one yielded different and somewhat contrasting results. While some authors could not demonstrate a single OC case with HPV, some concluded otherwise. Aims: 1. To identify the role of HPV as an independent risk factor for oral squamous cell carcinoma (OSCC). 2. To calculate the prevalence of HPV in local population. Settings and Design: Biopsy specimens of 100 patients were analyzed in the study. They were tested for the presence of surrogate marker p16 to predict the involvement of HPV. Materials and Methods: OC samples with already proven histopathological diagnosis of (of all grades) without habits were taken as cases and were subjected to immunohistochemistry. Statistical Analysis Used: Descriptive statistics were taken in use along with inferential statistics. Results: Out of 100 patients, 6 patients showed positive results for the presence of p16 or HPV. The P value was P = 0.012, which was statistically significant. Conclusions: It can be concluded that despite the absence of any other risk factors, HPV can result in OSCC even in a developing and conservative nation like India.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed21    
    Printed0    
    Emailed0    
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal