Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Subscribe Search Contacts Login 
  • Users Online: 418
  • Home
  • Print this page
  • Email this page
CASE REPORT
Year : 2018  |  Volume : 30  |  Issue : 2  |  Page : 165-168

Clinical spectrum of osteopetrosis with secondary osteomyelitis of the mandible: Report of two cases


Department of Oral Medicine and Radiology, Tamil Nadu Government Dental College and Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Manoharan Preethi
Department of Oral Medicine and Radiology, Tamil Nadu Government Dental College and Hospital, Chennai - 600 003, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jiaomr.jiaomr_20_18

Rights and Permissions

Osteopetrosis is an inherited disorder of the bone caused by mutations in gene that encode for carbonic anhydrase. This results in defective osteoclast function leading to resorption defects and formation of bones that are extremely dense and prone to fractures. In addition, it causes a variety of clinical manifestations in endocrine, nervous, orthopedic, hematologic, nephrologic, and dental. Among dental manifestations, osteomyelitis is the most serious complication caused by compromised blood supply resulting from encroachment of the medullary spaces by cortical bone. There are three subtypes of the disease—an autosomal dominant form also known as Albers–Schonberg disease or ADO II, malignant recessive infantile form, and an intermediate form. The ADO II can have an extremely varied clinical presentation ranging from an accidental finding from routine radiographic examination to poor prognosis. Here, we present two cases of ADO II with varied clinical, radiographic, and biochemical manifestations and discuss their management and dental implications.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed230    
    Printed0    
    Emailed0    
    PDF Downloaded83    
    Comments [Add]    

Recommend this journal