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RESEARCH ARTICLE
Year : 2012  |  Volume : 24  |  Issue : 4  |  Page : 257-260

In vivo Estimation of Redox States with Autofluorescence Spectroscopy in Oral Submucous Fibrosis Patients: A Pilot Study


1 Postgraduate Trainee, Department of Oral Medicine and Radiology Meenakshi Annual Dental College. Chennai, Tamil Nadu, India
2 Professor, Department of Oral Medicine and Radiology, Meenakshi Annual Dental College, Chennai, Tamil Nadu, India
3 Professor, Department of Medical Physics and Lasers, College of Engineering, Anna University, Chennai, Tamil Nadu, India

Correspondence Address:
V Jayanth Kumar
Postgraduate Trainee, Department of Oral Medicine and Radiology Meenakshi Annual Dental College. Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.5005/jp-journals-10011-1309

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Oral submucous fibrosis (OSMF) is a common premalignant condition occurring in Southeast Asia and Indian subcontinent. An early diagnosis and prompt treatment with patient counseling helps in the cure of the disease. Aim: The aim of this pilot study is to study and assess the redox ratio in patients with OSMF and normal patients. Materials and methods: This pilot study was carried out on in 10 patients visiting the Oral Medicine Department of our institution. After a thorough history, clinical examination and incisional biopsy the proven cases of OSMF were taken up for autofluorescence study. The representative site in the buccal mucosa was chosen based on clinical examination and the site was subjected to excitation with a light of wavelength 350 and 450 nm. This corresponds to the excitation wavelength of NADH and FAD respectively. The resulting emission intensities were obtained and the redox ratio was calculated. For control, about 10 cases of age-matched patients who had the habit of tobacco usage but without any lesions were chosen. Results: The redox ratio of patients with OSMF was 0.58 t 0.08 and in normal patients was 0.37 ± 0.04. Inference: The redox ratio is an indication of metabolic activity of the tissue being examined- From this study it could be concluded that an increase in redox ratio with a decreased cellular activity is seen in patients with OSMF.


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