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RESEARCH ARTICLE
Year : 2012  |  Volume : 24  |  Issue : 1  |  Page : 20-23

Dapsone in the treatment of resistant oral erosive lichen planus: A clinical study


1 Professor, Department of Oral Medicine and Radiology, KVG Dental College, Sullia, Karnataka, India
2 Principal, Department of Oral Medicine and Radiology, Al Azhar Dental College, Thodupuzha, Kerala, India
3 Professor and Head, Department of Oral Medicine and Radiology Government Dental College, Calicut, Kerala, India

Correspondence Address:
A C Raj
Professor, Department of Oral Medicine and Radiology, KVG Dental College, Sullia, Karnataka
India
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Source of Support: None, Conflict of Interest: None


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Aims: This study was designed to evaluate the efficacy of Dapsone for treating erosive lichen planus and to observe side effects occurring for the drug during the treatment. Materials and methods: Twenty-two patients who were resistant to treatment with systemic antioxidants and topical vitamin were treated with systemic Dapsone 100 mg per day for 3 months. Improvement of signs and symptoms of the disease and the side effects of the drug were evaluated every 15 days and posttreatment recurrence of the disease was assessed after 6 months of treatment. Results: A significant improvement in the burning sensation and reduction in size of the erosive areas were noticed with a 3 months course of Dapsone therapy. Systemic side effects were minimal. A reduction in hemoglobin percentage of 0.92 gm from the baseline values was the only observed side effect Conclusion: Results of this study show that Dapsone is an effective drug in erosive lichen planus. Dapsone can be used as a steroid sparing agent when steroids are contraindicated. There are minimal side effects for Dapsone when used in the dose of 100 mg per day for 3 months.


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