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RESEARCH ARTICLE
Year : 2011  |  Volume : 23  |  Issue : 4  |  Page : 536-538

Salivary IGA levels in patients with oral submucous fibrosis: A study


1 Senior Lecturer, Department of Oral Medicine and Radiology, Chhattisgarh Dental College and Research Institute Rajnandgaon, Chhattisgarh, India
2 Reader, Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
3 Postgraduate Student, Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India

Correspondence Address:
Prashant Gupta
Senior Lecturer, Department of Oral Medicine and Radiology, Chhattisgarh Dental College and Research Institute, Sundra, Rajnandgaon, Chhattisgarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.5005/jp-journals-10011-1217

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Background: Salivary IgA forms the major source of defense in the oral cavity. It comes from the secretory epithelial cells and also from the vascular compartment. Oral submucous fibrosis patients have progressive fibrosis of oral mucosa secondary to betel quid chewing. Chewing betel quid has got an effect on the immunoglobulin profile in saliva, hence we studied the salivary IgA levels in these patents. Aim: The aim of the present study was to evaluate the salivary IgA levels in OSMF patients. Materials and methods: Study comprised of 20 OSMF cases which were clinically diagnosed and 40 smokeless tobacco chewers and 20 controls. Results: Salivary IgA levels were reduced in smokeless tobacco chewers and increased in OSMF patients when compared with controls. Conclusion: Altered IgA levels in saliva of smokeless tobacco chewers probably creates an immunological incompetence which could promote effect of cotinine on oral mucosa and result in fibrosis.


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