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Year : 2011  |  Volume : 23  |  Issue : 4  |  Page : 513-517

Xerostomia, its association with oral manifestation and ocular involvement: A clinical and biochemical study

1 Reader, Department of Oral Medicine and Radiology, KMCT Dental College, Kozhikode, Kerala, India
2 Principal, MAHE Institute of Dental Sciences, MAHE Union Territory Puducherry, Puducherry, India

Correspondence Address:
Deepak Daryani
No. 2, Defence Colony, 1st Main, Indira Nagar, Bengaluru-560038, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.5005/jp-journals-10011-1212

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Introduction: Xerostomia is the subjective symptom of dryness of mouth. Although xerostomia is not a disease, it may herald the onset or signal the presence of a number of serious systemic diseases and condition. Objective: The study was conducted to evaluate oral manifestations associated with xerostomia, to establish relation between salivary gland function and lacnmal gland function in individuals with xerostomia and to establish the changes in composition of saliva in patents with xerostomia. Materials and methods: The study is randomized case-control study involving a total of 60 adult individuals. The study group consisted of 30 adult individuals reporting with chief complaint of xerostomia. Control group consisted of 30 healthy age and gender matched individuals. Each group was further divided into five subgroups according to the age. Patents with known cause of xerostomia like diabetes, salivary diseases, radiation therapy, chemotherapy, xerogenic medications were excluded from the study- A detailed case history was taken, the associated oral symptoms and clinical signs were recorded. The study population was subjected to xerostomia questionnaires to assess the severity of dry mouth. Sialometry was done to assess the salivary gland function by measuring unstimulated whole saliva, stimulated whole saliva and stimulated parotid saliva Sialochemistry of collected saliva was done and concentration of salivary electrolytes and total protein was assessed. All the subjects were given ophthalmic examination to evaluate lacrimal gland function. Results and conclusion: Xerostomia is a distressing symptom affecting patients' quality of life. It affects females more than males. Unstimulated whole saliva is the better indicator of salivary gland function. Salivary concentration of sodium, chloride and total protein is higher in patients with xerostomia. Multiglandular hypofunction may be phenomenon coexisting with xerostomia which often goes undiagnosed.

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