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RESEARCH ARTICLE
Year : 2011  |  Volume : 23  |  Issue : 4  |  Page : 495-497

Estimation of pre- and postradiotherapy blood selenium-dependent glutathione peroxidase levels in oral squamous cell carcinoma patients


1 Reader and Head, Department of OMR, Maharaja Ganga Singh Dental College and Research Centre, Sri Ganganagar, Rajasthan, India
2 Professor and Head, Department of OMR, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh, India

Correspondence Address:
Jitendra Sachdeo
Reader and Head, Department of OMR, 141, Sindhi Camp, Akola-444001, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.5005/jp-journals-10011-1208

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Radiotherapy has been used successfully in the treatment of cancer for many years. It can be used as only treatment or in combination with other treatment modalities. Blood samples were collected of oral squamous cell carcinoma patients attending the Department of Oral Medicine and Radiology, Government Dental College and Hospital, RST Cancer Hospital and Research Centre. Nagpur and Department of Radiotherapy and Department of Biochemistry. Government Medical College and Hospital, Nagpur, before and after sixth week of radiation therapy. The effect of radiation on oral squamous cell carcinoma has been studied using activity of glutathione peroxidase enzyme- GPX Enzyme activity was significantly reduced in RBC hemolysate of oral cancer patient showing lack of antioxidant defense. Radiation treatment further inactivates the GPX enzyme, though insignificantly, by lipid peroxidation making system further inefficient.


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